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A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?

Abstract:

The nucleus pulposus (NP) of the intervertebral disc in cattle and humans shows the most dramatic changes with aging of any cartilaginous tissue. In humans, notochordal cells disappear from the NP and are replaced with chondrocytic cells by adolescence. However, notochordal cells of the NP persist into adult life in some species, such as rats and rabbits. Therefore, comparison of the metabolic activity of notochordal and nonnotochordal cells is considered to be important for determining the t...

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Publication status:
Published

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Publisher copy:
10.1089/ten.tea.2009.0250

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
Mary Ann Liebert Inc.
Journal:
Tissue engineering. Part A
Volume:
15
Issue:
12
Pages:
3835-3846
Publication date:
2009-12-05
DOI:
EISSN:
1937-335X
ISSN:
1937-3341
URN:
uuid:eceb0625-7117-499d-bae9-e912e7082fcb
Source identifiers:
239251
Local pid:
pubs:239251

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