A phenotypic comparison of proteoglycan production of intervertebral disc cells isolated from rats, rabbits, and bovine tails; which animal model is most suitable to study tissue engineering and biological repair of human disc disorders?

Journal article

The nucleus pulposus (NP) of the intervertebral disc in cattle and humans shows the most dramatic changes with aging of any cartilaginous tissue. In humans, notochordal cells disappear from the NP and are replaced with chondrocytic cells by adolescence. However, notochordal cells of the NP persist into adult life in some species, such as rats and rabbits. Therefore, comparison of the metabolic activity of notochordal and nonnotochordal cells is considered to be important for determining the t...

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Authors: Miyazaki, T; Kobayashi, S; Takeno, K; Meir, A; Urban, J

• Publication status: Published
• Publisher: Mary Ann Liebert Inc.
• Journal: Tissue engineering. Part A
• Volume: 15
• Issue: 12
• Pages: 3835-3846
• Publication date: 2009-12-01
• DOI: 10.1089/ten.tea.2009.0250
• EISSN: 1937-335X
• ISSN: 1937-3341
• Language: English
• Keywords: Models, Biological; Humans; Wound Healing; Phenotype; Animals; Tail; Cell Separation; Male; Tissue Engineering; Cells, Cultured; Cell Shape; Intervertebral Disc; Disease Models, Animal; Cattle; Rabbits; Proteoglycans; Spinal Diseases; Rats; Glycosaminoglycans; Extracellular Space