SLCO1B1 variants and statin-induced myopathy--a genomewide study.

Journal article

BACKGROUND: Lowering low-density lipoprotein cholesterol with statin therapy results in substantial reductions in cardiovascular events, and larger reductions in cholesterol may produce larger benefits. In rare cases, myopathy occurs in association with statin therapy, especially when the statins are administered at higher doses and with certain other medications. METHODS: We carried out a genomewide association study using approximately 300,000 markers (and additional fine-mapping) in 85 sub...

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Authors: Link, E; Parish, S; Armitage, J; Bowman, L; Heath, S

• Publication status: Published
• Journal: New England journal of medicine
• Volume: 359
• Issue: 8
• Pages: 789-799
• Publication date: 2008-08-01
• DOI: 10.1056/nejmoa0801936
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: Female; Arterial Occlusive Diseases; Polymorphism, Single Nucleotide; Humans; Muscular Diseases; Organic Anion Transporters; Chromosomes, Human, Pair 12; Aged; Myocardial Infarction; Risk; Simvastatin; Middle Aged; SEARCH Collaborative Group; Genetic Markers; Diabetes Mellitus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Genotype