A mathematical model for fibro-proliferative wound healing disorders.

Journal article

The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical treatments are thus unreliable. In this paper, the authors apply an existing deterministic mathemat...

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Authors: Olsen, L; Sherratt, J; Maini, P

• Publication status: Published
• Journal: Bulletin of mathematical biology
• Volume: 58
• Issue: 4
• Pages: 787-808
• Publication date: 1996-07-01
• DOI: 10.1016/0092-8240(96)00003-1
• EISSN: 1522-9602
• ISSN: 0092-8240
• Language: English
• Keywords: Wound Healing; Animals; Mathematics; Adult; Skin; Humans; Growth Substances; Models, Biological; Fibroblasts; Collagen; Cell Division