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Journal article

Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

Abstract:

All eukaryotic cellular mRNAs contain a 5' m(7)GpppN cap. In addition to conferring stability to the mRNA, the cap is required for pre-mRNA splicing, nuclear export and translation by providing an anchor point for protein binding. In translation, the interaction between the cap and the eukaryotic initiation factor 4E (eIF4E) is important in the recruitment of the mRNAs to the ribosome. Human 4EHP (h4EHP) is a homologue of eIF4E. Like eIF4E it is able to bind the cap but it appears to play a d...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2007.02.019

Authors


Rosettani, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Vismara, MG More by this author
Rusconi, L More by this author
Cameron, AD More by this author
Journal:
Journal of molecular biology
Volume:
368
Issue:
3
Pages:
691-705
Publication date:
2007-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:ecdb06b6-4998-4726-bac7-ede20fac6562
Source identifiers:
375126
Local pid:
pubs:375126

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