- Abstract:
-
All eukaryotic cellular mRNAs contain a 5' m(7)GpppN cap. In addition to conferring stability to the mRNA, the cap is required for pre-mRNA splicing, nuclear export and translation by providing an anchor point for protein binding. In translation, the interaction between the cap and the eukaryotic initiation factor 4E (eIF4E) is important in the recruitment of the mRNAs to the ribosome. Human 4EHP (h4EHP) is a homologue of eIF4E. Like eIF4E it is able to bind the cap but it appears to play a d...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.jmb.2007.02.019
-
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- Journal:
- Journal of molecular biology
- Volume:
- 368
- Issue:
- 3
- Pages:
- 691-705
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:ecdb06b6-4998-4726-bac7-ede20fac6562
- Source identifiers:
-
375126
- Local pid:
- pubs:375126
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
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