In vivo biodistribution and efficacy of peptide mediated delivery.

Journal article

To transverse the plasma membrane and gain access to the cellular interior is one of the major obstacles for many novel pharmaceutical molecules. Since the late 1990s, cell-penetrating peptides (CPPs) have been utilized as transport vectors for a broad spectrum of 'biological cargoes', ranging from inert gold particles to multifaceted macromolecules such as proteins and plasmids. Numerous studies have shown that CPPs are efficient carriers for bioactive cargoes in vitro. However, even though ...

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Authors: Järver, P; Mäger, I; Langel, Ü

• Journal: Trends in pharmacological sciences
• Volume: 31
• Issue: 11
• Pages: 528-535
• Publication date: 2010-11-01
• DOI: 10.1016/j.tips.2010.07.006
• EISSN: 1873-3735
• ISSN: 0165-6147
• Language: English
• Keywords: Anti-Inflammatory Agents, Non-Steroidal; Protein Transport; Antineoplastic Agents; Drug Carriers; Cell Membrane Permeability; Cell-Penetrating Peptides; Inflammation; Neoplasms; RNA Interference; Proteins; Cell Membrane; Humans; Tissue Distribution; RNA, Small Interfering; Animals; Oligonucleotides