Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.

Journal article

This study is concerned with the role of impulse activity and synaptic transmission in early thalamocortical development. Disruption of the gene encoding SNAP-25, a component of the soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor complex required for regulated neuroexocytosis, eliminates evoked but not spontaneous neurotransmitter release (Washbourne et al., 2002). The Snap25 null mutant mouse provides an opportunity to test whether synaptic activity is required f...

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Authors: Molnár, Z; López-Bendito, G; Small, J; Partridge, L; Blakemore, C

• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 22
• Issue: 23
• Pages: 10313-10323
• Publication date: 2002-12-01
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Antigens, Differentiation; Neural Pathways; Nerve Tissue Proteins; Heterozygote; Synaptic Transmission; Electrophysiology; Thalamus; Homozygote; Prosencephalon; Synapses; Phenotype; Membrane Proteins; Evoked Potentials; Macromolecular Substances; Animals; Cerebral Cortex; Mice, Inbred C57BL; Mice, Knockout; Synaptosomal-Associated Protein 25; Carbocyanines; Mice; Coloring Agents