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Normal development of embryonic thalamocortical connectivity in the absence of evoked synaptic activity.

Abstract:

This study is concerned with the role of impulse activity and synaptic transmission in early thalamocortical development. Disruption of the gene encoding SNAP-25, a component of the soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor complex required for regulated neuroexocytosis, eliminates evoked but not spontaneous neurotransmitter release (Washbourne et al., 2002). The Snap25 null mutant mouse provides an opportunity to test whether synaptic activity is required f...

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Authors


Molnár, Z More by this author
López-Bendito, G More by this author
Partridge, LD More by this author
Blakemore, C More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
22
Issue:
23
Pages:
10313-10323
Publication date:
2002-12-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:eccb925f-087b-454d-97f7-402345520414
Source identifiers:
113708
Local pid:
pubs:113708

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