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Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.

Abstract:

Recent work has indicated that oxygen-sensing mechanism(s) resembling those controlling erythropoietin production operate in many non-erythropoietin-producing cells. To pursue the implication that such a system might control other genes, we studied oxygen-regulated expression of mRNAs for vascular endothelial growth factor, platelet-derived growth factor (PDGF) A and B chains, placental growth factor (PLGF), and transforming growth factor in four different cell lines and compared the characte...

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Publication status:
Published

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Authors


Gleadle, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
The American journal of physiology
Volume:
268
Issue:
6 Pt 1
Pages:
C1362-C1368
Publication date:
1995-06-05
ISSN:
0002-9513
URN:
uuid:ecc7349b-6bb7-4cc9-9a62-bbe63e84b61e
Source identifiers:
27987
Local pid:
pubs:27987

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