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Journal article

Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.

Abstract:

RATIONALE: Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for predictive molecular biomarkers and the identification of novel molecular targets for chemoprevention and therapeutic strategies. For technical reasons, previous attempts to analy...

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Publisher copy:
10.1164/rccm.201001-0005oc

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Journal:
American journal of respiratory and critical care medicine
Volume:
182
Issue:
1
Pages:
83-91
Publication date:
2010-07-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:ecc2e148-37f6-42e1-86d7-10fd5b8bdadf
Source identifiers:
324308
Local pid:
pubs:324308

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