Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.

Journal article

AIMS/HYPOTHESIS: Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet (HFD). We used functional genomic technologies to document molecular mechanisms associated with diet-induced NAFLD. MATERIALS AND METHODS: Male 129S6 mice were fed a diet containing 40% fat (high-fat diet, HFD) for 15 weeks. Glucose tolerance, in vivo insulin secretion, plasma lipid profile and adiposity were determined. P...

Expand abstract

Authors: Toye, A; Dumas, M; Blancher, C; Rothwell, A; Fearnside, J

• Publication status: Published
• Journal: Diabetologia
• Volume: 50
• Issue: 9
• Pages: 1867-1879
• Publication date: 2007-09-01
• DOI: 10.1007/s00125-007-0738-5
• EISSN: 1432-0428
• ISSN: 0012-186X
• Language: English
• Keywords: Animals; Glucose Tolerance Test; Mice, Inbred Strains; Transcription, Genetic; Diet; Genetic Predisposition to Disease; Insulin; Liver; Animal Feed; Male; Lipids; Kinetics; Mice, Inbred BALB C; Mice; Fatty Liver; Insulin Resistance; Dietary Fats