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Journal article

Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice.

Abstract:

AIMS/HYPOTHESIS: Complex changes in gene expression are associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) promoted by feeding a high-fat diet (HFD). We used functional genomic technologies to document molecular mechanisms associated with diet-induced NAFLD. MATERIALS AND METHODS: Male 129S6 mice were fed a diet containing 40% fat (high-fat diet, HFD) for 15 weeks. Glucose tolerance, in vivo insulin secretion, plasma lipid profile and adiposity were determined. P...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-007-0738-5

Authors


Blancher, C More by this author
Rothwell, AR More by this author
Fearnside, JF More by this author
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Journal:
Diabetologia
Volume:
50
Issue:
9
Pages:
1867-1879
Publication date:
2007-09-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:ecb89a5a-e9d2-4b12-9607-eb70d37d825f
Source identifiers:
16638
Local pid:
pubs:16638

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