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Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

Abstract:

Background

Chronic hepatitis C (CHC) is associated with systemic insulin resistance, yet there are limited data on the tissue‐specific contribution in vivo to this adverse metabolic phenotype, and the effect of HCV cure.

Methods

We examined tissue‐specific insulin sensitivity in a cohort study involving 13 patients with CHC compared to 12 BMI‐matched healthy control subjects. All subjects underwent a two‐step clamp incorporating the use of stable isotopes to measure car... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/cen.13924

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Publisher:
Wiley Publisher's website
Journal:
Clinical Endocrinology Journal website
Volume:
90
Issue:
3
Pages:
440-448
Publication date:
2018-12-26
Acceptance date:
2018-12-20
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
Pubs id:
pubs:955037
URN:
uri:ecb5c76e-31fa-41bf-a6ca-b43ebb8afdec
UUID:
uuid:ecb5c76e-31fa-41bf-a6ca-b43ebb8afdec
Local pid:
pubs:955037
Language:
English
Keywords:

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