Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure
BackgroundChronic hepatitis C (CHC) is associated with systemic insulin resistance, yet there are limited data on the tissue‐specific contribution in vivo to this adverse metabolic phenotype, and the effect of HCV cure.
MethodsWe examined tissue‐specific insulin sensitivity in a cohort study involving 13 patients with CHC compared to 12 BMI‐matched healthy control subjects. All subjects underwent a two‐step clamp incorporating the use of stable isotopes to measure car... Expand abstract
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- Peer reviewed
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- Lim et al
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- © 2018 The Authors. Clinical Endocrinology Published by John Wiley and Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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