- Abstract:
-
Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker association analyses were assessed under an allelic model with Bonferroni correction for multiple testing. All statistical tests were two-sided. A rare inherited nonsynonymous variant in OGG1 (Gly308Glu), the ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/jnci/djt183
-
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- Journal:
- Journal of the National Cancer Institute
- Volume:
- 105
- Issue:
- 16
- Pages:
- 1249-1253
- Publication date:
- 2013-08-05
- DOI:
- EISSN:
-
1460-2105
- ISSN:
-
0027-8874
- URN:
-
uuid:ecb566aa-6fc0-4044-aeda-f9d027da4ef9
- Source identifiers:
-
414765
- Local pid:
- pubs:414765
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.
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