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Role of the oxidative DNA damage repair gene OGG1 in colorectal tumorigenesis.

Abstract:

Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance. We investigated whether rare inherited variants in other oxidative DNA damage repair genes predisposed to CRC. Single marker association analyses were assessed under an allelic model with Bonferroni correction for multiple testing. All statistical tests were two-sided. A rare inherited nonsynonymous variant in OGG1 (Gly308Glu), the ...

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Publication status:
Published

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Publisher copy:
10.1093/jnci/djt183

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Journal of the National Cancer Institute
Volume:
105
Issue:
16
Pages:
1249-1253
Publication date:
2013-08-05
DOI:
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:ecb566aa-6fc0-4044-aeda-f9d027da4ef9
Source identifiers:
414765
Local pid:
pubs:414765

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