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Journal article

The induction and maintenance of transplant tolerance engages both regulatory and anergic CD4+ T cells.

Abstract:

Therapeutic tolerance to self-antigens or foreign antigens is thought to depend on constant vigilance by Foxp3+ regulatory T cells (Tregs). Previous work using a pancreatic islet allograft model and a short pulse of CD3 antibody therapy has shown that CD8+ T cells become anergic and use TGFβ and coinhibitory signaling as their contribution to the tolerance process. Here, we examine the role of CD4+ T cells in tolerization by CD3 antibodies. We show that both Foxp3+ Tregs and CD4+ T cell anerg...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2017.00218

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Department:
Lincoln College
Role:
Author
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Sixth Framework Programme More from this funder
Fondation Centaure More from this funder
Fondation Day Solvay More from this funder
Juvenile Diabetes Research Foundation More from this funder
French National Institute of Health and Medical Research More from this funder
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
8
Pages:
218
Publication date:
2017-03-05
Acceptance date:
2017-02-15
DOI:
EISSN:
1664-3224
Pubs id:
pubs:686993
URN:
uri:ecac5835-8e27-4394-addd-8d11848c882b
UUID:
uuid:ecac5835-8e27-4394-addd-8d11848c882b
Local pid:
pubs:686993

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