Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia.

Journal article

In Cambodia, dengue virus (DENV) was first isolated in 1963 and has become endemic with peak epidemic during raining season. Since 2000, the Dengue National Control Program has reported from 10,000 to 40,000 cases per year with fatality rates ranging from 0.7 to 1.7. All four dengue serotypes are found circulating in Cambodia with alternative predominance of serotypes DENV-2 and DENV-3. The DENV-1 represents from 5% to 20% of all circulating viruses, depending upon the year. In this work, 79 ...

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Authors: Duong, V; Simmons, C; Gavotte, L; Viari, A; Ong, S

• Publication status: Published
• Journal: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
• Volume: 15
• Pages: 59-68
• Publication date: 2013-04-01
• DOI: 10.1016/j.meegid.2011.06.019
• EISSN: 1567-7257
• ISSN: 1567-1348
• Language: English
• Keywords: Genome, Viral; Genetic Variation; Molecular Sequence Data; Adult; Infant; Dengue; Quantitative Trait, Heritable; RNA, Viral; Humans; Genes, Viral; Phylogeny; Adolescent; Cambodia; Child, Preschool; Young Adult; Polymorphism, Genetic; Evolution, Molecular; Dengue Virus; Open Reading Frames; Selection, Genetic; Child