Nerve growth factor and pain mechanisms - ORA - Oxford University Research Archive

Abstract:: Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Denk, F., Bennett, D., & McMahon, S. (2017). Nerve growth factor and pain mechanisms. Annual Review of Neuroscience, 40(1), 307–325.

MLA Style

Denk, F, et al. “Nerve Growth Factor and Pain Mechanisms.” Annual Review of Neuroscience, vol. 40, no. 1, 2017, pp. 307–25.

Chicago Style

Denk, F, D Bennett, and S McMahon. 2017. “Nerve Growth Factor and Pain Mechanisms.” Annual Review of Neuroscience 40 (1): 307–25.
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Publisher copy:: 10.1146/annurev-neuro-072116-031121

Authors

+ Denk, F More by this author

Role:: Author

+ Bennett, D More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Clinical Neurosciences
Oxford college:: Green Templeton College
Role:: Author

+ McMahon, S More by this author

Role:: Author

Publisher:: Annual Reviews
Journal:: Annual Review of Neuroscience More from this journal
Volume:: 40
Issue:: 1
Pages:: 307-325
Publication date:: 2017-04-24
Acceptance date:: 2017-03-01
DOI:: 10.1146/annurev-neuro-072116-031121
EISSN:: 1545-4126
ISSN:: 0147-006X

Language:: English
Keywords:: p75

chronic pain

nerve growth factor

trkA
Pubs id:: pubs:692056
UUID:: uuid:eca67421-1984-4e7c-89f2-1ad120f075ab
Local pid:: pubs:692056
Source identifiers:: 692056
Deposit date:: 2017-05-05
ARK identifier:: ark:/29072/ora_eca6742119844e7c89f21ad120f075ab

Terms of use

Copyright holder:: Annual Reviews
Copyright date:: 2017
Notes:: The final version is available online from Annual Reviews at: https://doi.org/10.1146/annurev-neuro-072116-031121

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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