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Ovine atadenovirus, a novel and highly immunogenic vector in prime-boost studies of a candidate HIV-1 vaccine.

Abstract:

Ovine adenovirus type 7 (OAdV) is the prototype member of the genus Atadenovirus. No immunity to the virus has so far been detected in human sera. We describe the construction and evaluation of a candidate HIV-1 vaccine based on OAdV and its utilisation alone and in combination with plasmid-, human adenovirus type 5 (HAdV5; a Mastadenovirus)-, and modified vaccinia Ankara (MVA)-vectored vaccines. All vectors expressed HIVA, an immunogen consisting of HIV-1 clade A consensus Gag-derived protei...

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Publication status:
Published

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Authors


Bridgeman, A More by this author
Roshorm, Y More by this author
Lockett, LJ More by this author
Hopkins, R More by this author
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Journal:
Vaccine
Volume:
28
Issue:
2
Pages:
474-483
Publication date:
2009-12-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:eca5130c-e1b6-48df-8a5b-39c6e33f6835
Source identifiers:
67006
Local pid:
pubs:67006

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