Journal article icon

Journal article

Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY

Abstract:

The gut hormone peptide tyrosine tyrosine (PYY) is critical for maintaining islet integrity and restoring islet function following Roux-en-Y gastric bypass (RYGB). The expression of PYY and its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation of islet PYY by the proteolytic enzyme DPP-IV has not been investigated and the impact of DPP-IV inhibition on islet PYY function remains unexplored. Here we have addressed these gaps and their effects on glucose-st...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1111/dom.13113

Authors


More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Expand authors...
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Diabetes, Obesity and Metabolism Journal website
Volume:
20
Issue:
3
Pages:
571-581
Publication date:
2017-10-10
Acceptance date:
2017-09-05
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
Pubs id:
pubs:729346
URN:
uri:eca48f8a-c07d-46d3-a93b-442d6c5426e4
UUID:
uuid:eca48f8a-c07d-46d3-a93b-442d6c5426e4
Local pid:
pubs:729346
Paper number:
3

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP