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Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY

Abstract:

The gut hormone peptide tyrosine tyrosine (PYY) is critical for maintaining islet integrity and restoring islet function following Roux-en-Y gastric bypass (RYGB). The expression of PYY and its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation of islet PYY by the proteolytic enzyme DPP-IV has not been investigated and the impact of DPP-IV inhibition on islet PYY function remains unexplored. Here we have addressed these gaps and their effects on glucose-st...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/dom.13113

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Expand authors...
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
Diabetes, Obesity and Metabolism Journal website
Volume:
20
Issue:
3
Pages:
571-581
Publication date:
2017-10-10
Acceptance date:
2017-09-05
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
Pmid:
28892258
Source identifiers:
729346
Language:
English
Keywords:
Pubs id:
pubs:729346
UUID:
uuid:eca48f8a-c07d-46d3-a93b-442d6c5426e4
Local pid:
pubs:729346
Deposit date:
2017-10-02

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