Journal article
Early life microcirculatory plasticity and blood pressure changes in low birth weight infants born to normotensive mothers: a cohort study
- Abstract:
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BACKGROUND Capillary rarefaction (CR) is an established hallmark of essential hypertension (EH). The aim of this study was to examine early changes in capillary density (CD) and blood pressure (BP) in low birth weight (LBW) infants who are at risk of developing EH in later life.
METHODS We studied 77 LBW infants and 284 normal birth weight (NBW) infants, all born to mothers with normotension, in a longitudinal multicenter study. Intravital capillaroscopy was used to measure functional basal capillary density (BCD) and maximal capillary density (MCD) at birth, 3, 6, and 12 months.
RESULTS We found that LBW infants, born preterm and at term, had a significantly higher CD at birth, then underwent significant CR in the 1st 3 months culminating in a CD similar to that seen in NBW infants. NBW infants showed a gradual reduction in CD between birth and 12 months. Non-Caucasian ethnicity and preterm birth were significant predictors of a higher CD at birth. Systolic BP in NBW infants increased significantly from birth to 3 months, and we identified a significant negative correlation between systolic BP and MCD.
CONCLUSIONS This study has identified a process of early “accelerated capillary remodeling” in LBW infants, which corrects their higher CD at birth. This remodeling is unlikely to explain the CR seen in adult individuals with, or at risk of developing EH. Further follow-up studies are required to determine the timing and mechanisms involved in CR, which is likely to occur after the 1st year of life but before early adulthood.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 294.5KB, Terms of use)
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- Publisher copy:
- 10.1093/ajh/hpz034
Authors
- Publisher:
- Oxford University Press
- Journal:
- American Journal of Hypertension More from this journal
- Volume:
- 32
- Issue:
- 6
- Pages:
- 570–578
- Publication date:
- 2019-03-01
- Acceptance date:
- 2019-01-24
- DOI:
- EISSN:
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1941-7225
- ISSN:
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0895-7061
- Pmid:
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30821323
- Language:
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English
- Keywords:
- Pubs id:
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pubs:979811
- UUID:
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uuid:eca30a03-4b64-4293-8c28-2a5cc24ec757
- Local pid:
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pubs:979811
- Source identifiers:
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979811
- Deposit date:
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2019-03-05
Terms of use
- Copyright holder:
- Goloba et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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