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In vitro generation of mature human osteoclasts.

Abstract:

Mononuclear precursors of human osteoclasts are found in the CD14(+) monocyte fraction of circulating peripheral blood mononuclear cells (PBMCs). It is possible to generate osteoclasts in vitro from PBMCs cultured with macrophage colony-stimulating factor and receptor activator for nuclear factor κB ligand. In these cultures, however, it is not possible to distinguish the effect of a specific agent on osteoclast resorption activity as opposed to osteoclast differentiation. To produce a popula...

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Publication status:
Published

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Publisher copy:
10.1007/s00223-011-9530-0

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Journal:
Calcified tissue international
Volume:
89
Issue:
5
Pages:
389-395
Publication date:
2011-11-05
DOI:
EISSN:
1432-0827
ISSN:
0171-967X
URN:
uuid:eca15ba4-5313-41a9-9e9f-74ca934f5b66
Source identifiers:
186434
Local pid:
pubs:186434

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