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Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence

Abstract:

A surprising feature of most cytotoxic T lymphocytes (CTL) responding to influenza infection is that they recognize the unglycosylated (non-transmembrane) proteins of the virus, including the nucleoprotein. Recognition of cells that express nucleoprotein by CTL does not depend on a definite signal sequence within the protein, and the epitopes recognized can be defined with short synthetic peptides in vitro. Haemagglutinin (HA), the major transmembrane protein of the virus, is recognized by a ...

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Authors


Townsend, ARM More by this author
Brownlee, GG More by this author
Journal:
Nature
Volume:
324
Issue:
6097
Pages:
575-577
Publication date:
1986
ISSN:
0028-0836
URN:
uuid:ec927428-2744-4dfc-bd44-29b9ec0152ab
Source identifiers:
95056
Local pid:
pubs:95056
Language:
English

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