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Filaggrin null mutations associate with increased frequencies of allergen-specific CD4+ T-helper 2 cells in patients with atopic eczema.

Abstract:

BACKGROUND: Filaggrin null mutations associate with atopic eczema and also with asthma when present with eczema. However, while epidermal dysfunction is an important factor in disease pathogenesis, it is unclear how such dysfunction interacts with immune responses to contribute to cutaneous and other inflammatory atopic disease. OBJECTIVES: To gain a better understanding of the mechanisms underlying such predisposition in order to understand different disease phenotypes and possibly identify ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Medicine Division
Sherman, VJ More by this author
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Journal:
The British journal of dermatology
Volume:
163
Issue:
3
Pages:
544-549
Publication date:
2010-09-05
DOI:
EISSN:
1365-2133
ISSN:
0007-0963
URN:
uuid:ec90246f-484e-4cee-a3bd-4ad81f615e68
Source identifiers:
58613
Local pid:
pubs:58613

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