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Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

Abstract:

Expression of the macrophage mannose receptor is inhibited by interferon gamma (IFN-gamma), a T helper type 1 (Th-1)-derived lymphokine. Interleukin 4 (IL-4), a Th-2 lymphocyte product, upregulates major histocompatibility class II antigen expression but inhibits inflammatory cytokine production by macrophages. We have studied the effect of IL-4 on expression of the macrophage mannose receptor (MMR) by elicited peritoneal macrophages. We found that recombinant murine IL-4 enhances MMR surface...

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Publication status:
Published

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Publisher copy:
10.1084/jem.176.1.287

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Medicine Division, Clinical Medicine
Role:
Author
Journal:
The Journal of experimental medicine
Volume:
176
Issue:
1
Pages:
287-292
Publication date:
1992-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:ec8d5529-5d34-4032-8fb5-20ee00839cea
Source identifiers:
21935
Local pid:
pubs:21935

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