Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils.

Journal article

MT6-MMP/MMP-25 is the latest member of the membrane-type matrix metalloproteinase (MT-MMP) subgroup in the MMP family and is expressed in neutrophils and some brain tumors. The proteolytic activity of MT6-MMP has been studied using recombinant catalytic fragments and shown to degrade several components of the extracellular matrix. However, the activity is possibly modulated further by the C-terminal hemopexin-like domain, because some MMPs are known to interact with other proteins through thi...

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Authors: Matsuda, A; Itoh, Y; Koshikawa, N; Akizawa, T; Yana, I

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 278
• Issue: 38
• Pages: 36350-36357
• Publication date: 2003-09-01
• DOI: 10.1074/jbc.m301509200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: GPI-Linked Proteins; Epitopes; Protein Structure, Tertiary; Amino Acid Motifs; Silver Staining; Clusterin; Hydrogen-Ion Concentration; Matrix Metalloproteinases, Membrane-Associated; Recombinant Proteins; Molecular Chaperones; Animals; Cell Line; Neutrophils; Glycoproteins; Matrix Metalloproteinases; Models, Genetic; Catalytic Domain; Genetic Vectors; Transfection; Precipitin Tests; Humans; Protein Binding; Plasmids; Gene Expression Regulation; COS Cells; DNA, Complementary; Kinetics; Furin; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Chromatography, Gel; Dose-Response Relationship, Drug; Time Factors; Cell Line, Tumor; Dogs