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Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance.

Abstract:

Anti-lymphocyte-depleting antibodies have increasingly been utilized in the clinic as induction therapy aiming to improve transplantation outcomes by reducing the need for long-term immunosuppression. However, maintenance immunosuppression is still required as lymphocyte reconstitution through homeostatic proliferation, partially driven by IL-7, continues to replenish tolerance-refractory immune cells capable of rejection. In murine models of MHC mismatched skin grafting, we investigated whet...

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Publication status:
Published

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Publisher copy:
10.1111/ajt.12756

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More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Publisher:
Blackwell Publishing Ltd
Journal:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Volume:
14
Issue:
7
Pages:
1678-1689
Publication date:
2014-07-05
DOI:
EISSN:
1600-6143
ISSN:
1600-6135
URN:
uuid:ec69ece0-8792-4a3d-88d6-ce5afee43777
Source identifiers:
465893
Local pid:
pubs:465893

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