Atherosclerotic lesions in genetically modified mice quantified in vivo by non-invasive high-resolution magnetic resonance microscopy.

Journal article

We have previously shown that magnetic resonance microscopy (MRM) accurately quantifies atherosclerosis in Apolipoprotein E deficient (ApoE(-/-)) mice aged 36-84 weeks. The present study tests MRM in the quantification of aortic atherosclerosis over a broader range of lesion severity. Younger mice with less advanced disease were imaged in order to evaluate sensitivity, specificity and maximum practical resolution of MRM. Nineteen mice underwent in vivo MRM. Wall area measurements by MRM and l...

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Authors: Choudhury, R; Aguinaldo, J; Rong, J; Kulak, J; Kulak, A

• Publication status: Published
• Journal: Atherosclerosis
• Volume: 162
• Issue: 2
• Pages: 315-321
• Publication date: 2002-06-01
• DOI: 10.1016/s0021-9150(01)00730-4
• EISSN: 1879-1484
• ISSN: 0021-9150
• Language: English
• Keywords: Aorta, Abdominal; Magnetic Resonance Imaging; Apolipoproteins E; Mice, Knockout; Arteriosclerosis; Animals; Aortic Diseases; Mice; Humans; Severity of Illness Index; Mice, Inbred C57BL; Reproducibility of Results; Sensitivity and Specificity