The GATA family (vertebrates and invertebrates).

Journal article

Abstract:: Over the past year, vertebrate GATA factors have been found to participate directly in several signal-transduction pathways. Smad3, phosphorylated by TGF-beta signalling, interacts with GATA3 to induce differentiation of T helper cells. Hypertrophic stimuli act through RhoA GTPase and ROCK kinase to activate GATA4 in cardiac myocytes. In the liver, GATA4 is elevated by BMP and FGF signalling, and is able to bind to chromatin targets. Invertebrate GATA factors play a central role in specifying the mesendoderm.

Journal:: Current opinion in genetics and development More from this journal
Volume:: 12
Issue:: 4
Pages:: 416-422
Publication date:: 2002-08-01
DOI:: 10.1016/s0959-437x(02)00319-2
EISSN:: 1879-0380
ISSN:: 0959-437X

Language:: English
Keywords:: Endoderm

Muscle, Smooth

DNA-Binding Proteins

Multigene Family

Invertebrates

Biological Evolution

Myocardium

Drosophila

Mesoderm

Animals

Vertebrates
Pubs id:: pubs:106897
UUID:: uuid:ec5adbb6-2b9e-4284-b6f7-57fc73de10f2
Local pid:: pubs:106897
Source identifiers:: 106897
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_ec5adbb62b9e4284b6f757fc73de10f2

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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