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Journal article

Inhibitory receptor expression on memory CD8 T cells following Ad vector immunization

Abstract:

T cells are an important component of immune responses, and their function is influenced by their expression of inhibitory receptors. Immunization with alternative serotype adenovirus (Ad) vectors induces highly functional T cell responses with lower programmed cell death 1 (PD-1) expression and increased boostability relative to Ad5 vectors. However, a detailed phenotypic characterization of other inhibitory receptors is lacking, and it is unknown whether Ad5-induced CD8 T cells eventually r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.vaccine.2016.08.048

Authors


Penaloza-MacMaster, P More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Larocca, R More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
34
Issue:
41
Pages:
4955-4963
Publication date:
2016-09-05
Acceptance date:
2016-08-14
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
Pubs id:
pubs:640990
URN:
uri:ec57db35-d5c3-4da8-88a7-ebe06fe28cd2
UUID:
uuid:ec57db35-d5c3-4da8-88a7-ebe06fe28cd2
Local pid:
pubs:640990
Language:
English
Keywords:

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