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Mutations in ATP-sensitive K+ channel genes cause transient neonatal diabetes and permanent diabetes in childhood or adulthood.

Abstract:

Transient neonatal diabetes mellitus (TNDM) is diagnosed in the first 6 months of life, with remission in infancy or early childhood. For approximately 50% of patients, their diabetes will relapse in later life. The majority of cases result from anomalies of the imprinted region on chromosome 6q24, and 14 patients with ATP-sensitive K+ channel (K(ATP) channel) gene mutations have been reported. We determined the 6q24 status in 97 patients with TNDM. In patients in whom no abnormality was iden...

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Publisher copy:
10.2337/db07-0043

Authors


Flanagan, SE More by this author
Mackay, DJ More by this author
Edghill, EL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
Diabetes
Volume:
56
Issue:
7
Pages:
1930-1937
Publication date:
2007-07-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:ec578f77-d023-468c-949c-7130e4024827
Source identifiers:
19526
Local pid:
pubs:19526

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