Journal article

Simultaneous Detection of Homocysteine and Cysteine in the Presence of Ascorbic Acid and Glutathione Using a Nanocarbon Modified Electrode

Abstract:: The simultaneous electrochemical detection of homocysteine and cysteine using an absorbed ortho-quinone species, catechol, at the nanocarbon modified glassy carbon electrode was achieved via 1,4-Michael addition reaction. The detection was done in the presence and the absence of each other as well as with both glutathione and ascorbic acid present in order to investigate the selectivity of homocysteine and cysteine. A determination of homocysteine sensitivity is (0.882±0.296)nAnM-1 with a LOD of ca. 11nM and cysteine sensitivity is (7.501±0.202)mAμM-1 with a LOD of ca. 5.0μM within a range of 0-0.1mM. © 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

Publication status:: Published

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APA Style

Lee, P., Lowinsohn, D., & Compton, R. (2014). Simultaneous Detection of Homocysteine and Cysteine in the Presence of Ascorbic Acid and Glutathione Using a Nanocarbon Modified Electrode. ELECTROANALYSIS, 26(7), 1488–1496.

MLA Style

Lee, P, et al. “Simultaneous Detection of Homocysteine and Cysteine in the Presence of Ascorbic Acid and Glutathione Using a Nanocarbon Modified Electrode.” ELECTROANALYSIS, vol. 26, no. 7, 2014, pp. 1488–96.

Chicago Style

Lee, P, D Lowinsohn, and R Compton. 2014. “Simultaneous Detection of Homocysteine and Cysteine in the Presence of Ascorbic Acid and Glutathione Using a Nanocarbon Modified Electrode.” ELECTROANALYSIS 26 (7): 1488–96.
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Publisher copy:: 10.1002/elan.201400091

Authors

+ Lee, P More by this author

Role:: Author

+ Lowinsohn, D More by this author

Role:: Author

+ Compton, R More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Physical & Theoretical Chem
Role:: Author

Journal:: ELECTROANALYSIS More from this journal
Volume:: 26
Issue:: 7
Pages:: 1488-1496
Publication date:: 2014-07-01
DOI:: 10.1002/elan.201400091
EISSN:: 1521-4109
ISSN:: 1040-0397

Language:: English
Keywords:: 1,4-Michael addition reaction

Homocysteine

Carbon electrodes

Nanocarbon

Cysteine

Thiols

ortho-Quinone

Catechol
Pubs id:: pubs:472099
UUID:: uuid:ec51c921-b7b5-44be-9c16-bb4219c5718a
Local pid:: pubs:472099
Source identifiers:: 472099
Deposit date:: 2014-07-09
ARK identifier:: ark:/29072/ora_ec51c921b7b544be9c16bb4219c5718a

Terms of use

Copyright date:: 2014

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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