Palladium-catalyzed synthesis of benzimidazoles and quinazolinones from common precursors.

Journal article

N-(o-Halophenyl)imidoyl chlorides and the corresponding imidates are easily prepared and can be utilized as complementary precursors for the synthesis of important heterocycles. The synthesis of N-substituted benzimidazoles was possible from the palladium-catalyzed reaction of both classes of substrate with a variety of N-nucleophiles. The use of the imidate precursor for the synthesis of N-substituted quinazolinones by incorporation of a palladium-catalyzed aminocarbonylation reaction has al...

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Authors: Sadig, J; Foster, R; Wakenhut, F; Willis, M

• Publication status: Published
• Journal: Journal of organic chemistry
• Volume: 77
• Issue: 21
• Pages: 9473-9486
• Publication date: 2012-11-01
• DOI: 10.1021/jo301805d
• EISSN: 1520-6904
• ISSN: 0022-3263
• Language: English
• Keywords: Catalysis; Quinazolinones; Benzimidazoles; Molecular Structure; Palladium; Stereoisomerism