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Journal article

Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.

Abstract:

TFAP4, a basic helix-loop-helix transcription factor that regulates the expression of a multitude of genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition, is up-regulated in colorectal cancer and a number of other human malignancies. We have found that, during the G2 phase of the cell division cycle, TFAP4 is targeted for proteasome-dependent degradation by the SCF(βTrCP) ubiquitin ligase. This event requires phosphorylation of TFAP4 on a...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m114.549535

Authors


D'Annibale, S More by this author
Magliozzi, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
The Journal of biological chemistry
Volume:
289
Issue:
11
Pages:
7730-7737
Publication date:
2014-03-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ec434050-a5a1-4c44-915f-8c23dc031ffb
Source identifiers:
458459
Local pid:
pubs:458459

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