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Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria.

Abstract:

A randomized, open-label comparison of artesunate and quinine was conducted in 113 adults with clinically severe falciparum malaria in western Thailand. Mortality was 12% with artesunate and 22% with quinine treatment (relative risk, 0.53; 95% confidence interval, 0.23-1.26; P=.22). Multiple logistic regression analysis found admission plasma lactate level, Glasgow Coma Scale score, and total serum bilirubin level to be independent risk factors for death. Coma recovery and times to normalize ...

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Publication status:
Published

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Publisher copy:
10.1086/375059

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Chierakul, W More by this author
Dondorp, A More by this author
Ruangveerayuth, R More by this author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
37
Issue:
1
Pages:
7-16
Publication date:
2003-07-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:ec3d940c-e08c-4772-8ecf-8437865fcd07
Source identifiers:
15910
Local pid:
pubs:15910

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