Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study.

Journal article

IMPORTANCE: Most patients with neuromyelitis optica (NMO) and many with NMO spectrum disorder have autoantibodies against aquaporin-4 (AQP4-Abs), but recently, myelin-oligodendrocyte glycoprotein antibodies (MOG-Abs) have been found in some patients. Here, we showed that patients with NMO/NMOSD with MOG-Abs demonstrate differences when compared with patients with AQP4-Abs. OBJECTIVE: To characterize the features of patients with NMO/NMOSD with MOG-Abs and compare them with patients with AQP4-...

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Authors: Kitley, J; Waters, P; Woodhall, M; Leite, M; Murchison, A

• Publication status: Published
• Journal: JAMA neurology
• Volume: 71
• Issue: 3
• Pages: 276-283
• Publication date: 2014-03-01
• DOI: 10.1001/jamaneurol.2013.5857
• EISSN: 2168-6157
• ISSN: 2168-6149
• Language: English
• Keywords: Neuromyelitis Optica; Myelin-Oligodendrocyte Glycoprotein; Hirudins; Severity of Illness Index; Recombinant Proteins; Alcohol Oxidoreductases; Age of Onset; Disability Evaluation; DNA-Binding Proteins; Autoantibodies; Follow-Up Studies; Humans; Adult; Female; Male; Aquaporin 4; Sex Factors; Urokinase-Type Plasminogen Activator; Age Factors; Middle Aged