Journal article
Self-rated health status and risk of incident stroke in 0.5 million Chinese adults: The China Kadoorie Biobank Study
- Abstract:
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Background and purpose
Self-rated health (SRH) is a consistent and strong predictor of all-cause and cardiovascular mortality in various populations. However, the associations between SRH measures and risk of first-ever or recurrent stroke were rarely explored. We thus aim to prospectively investigate the associations between SRH measures and risk of total and subtypes of stroke in Chinese population.
Methods
A total of 494,113 participants from the China Kadoorie Biobank without prior heart diseases or cancer (486,541 without stroke and 7,572 with stroke) were followed from baseline (2004 to 2008) until December 31, 2013. General and age-comparative SRH were obtained from baseline questionnaires. First-ever stroke or recurrent events were ascertained through linkage to disease registry system and health insurance data.
Results
We identified 27,662 first-ever stroke and 2,909 recurrent events during an average of 7.0 years of follow-up. Compared with excellent general SRH, the hazard ratios (HRs) and 95% confidence intervals (CIs) for first-ever stroke associated with good, fair, and poor general SRH were 1.04 (1.00 to 1.08), 1.19 (1.15 to 1.23), and 1.49 (1.42 to 1.56) in the multivariate model, respectively. Compared with better age-comparative SRH, the HRs (95% CIs) of same and worse age-comparative SRH were 1.13 (1.10 to 1.17) and 1.51 (1.45 to 1.58), respectively. The relations of SRH measures with ischemic stroke, hemorrhagic stroke, and recurrent stroke were similar to that with total first-ever stroke. However, the magnitude of associations was much stronger for fatal stroke than for non-fatal stroke.
Conclusions
This large-scale prospective cohort suggests that self-perceived health status is associated with incident stroke, regardless of stroke subtype.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 941.3KB, Terms of use)
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- Publisher copy:
- 10.5853/jos.2017.01732
Authors
- Publisher:
- Korean Stroke Society
- Journal:
- Journal of Stroke More from this journal
- Volume:
- 20
- Issue:
- 2
- Pages:
- 247-257
- Publication date:
- 2018-05-31
- Acceptance date:
- 2018-03-18
- DOI:
- EISSN:
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2287-6405
- ISSN:
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2287-6391
- Pmid:
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29886721
- Language:
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English
- Keywords:
- Pubs id:
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pubs:856988
- UUID:
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uuid:ec37bb78-a9ea-4fa7-b4d4-6c8691aa5d4a
- Local pid:
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pubs:856988
- Source identifiers:
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856988
- Deposit date:
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2018-10-11
Terms of use
- Copyright holder:
- Korean Stroke Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Korean Stroke Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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