Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.

Journal article

Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. In addition to its structural role, elastin is a regulator that maintains homeostasis through biologic signaling. Genetically determined minor modifications in elastin and collagen in the aorta could influence the onset and evolution of arterial pathology, such as hypertension and its complications. We previously demonstrated that the inbred Brown Norway (BN) rat shows an aortic elastin...

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Authors: Gauguier, D; Behmoaras, J; Argoud, K; Wilder, S; Pradines, C

• Publication status: Published
• Journal: Hypertension
• Volume: 45
• Issue: 3
• Pages: 460-466
• Publication date: 2005-03-01
• DOI: 10.1161/01.hyp.0000155213.83719.7c
• EISSN: 1524-4563
• ISSN: 0194-911X
• Language: English
• Keywords: Rats, Inbred BN; Female; Rats; Quantitative Trait Loci; Aorta; Animals; Male; Rats, Inbred Strains; Elastin; Genetic Linkage; Chromosome Mapping; Hybridization, Genetic; Phenotype