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Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond.

Abstract:

The autoimmune thyroid diseases (AITDs) including Graves' disease (GD) and autoimmune hypothyroidism (AIH) are the commonest of the autoimmune conditions affecting 2-5% of the western population. Twin studies have clearly demonstrated that AITDs are caused by a combination of both environmental and genetic factors. Association of the HLA class II region with AITD has been documented for over 20 years now, but the primary aetiological variant in this region remains unknown. More recently the C...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Journal:
Clinical and experimental immunology
Volume:
136
Issue:
1
Pages:
1-10
Publication date:
2004-04-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:ec2f87e9-375a-40b1-8389-f8dadefa3665
Source identifiers:
176350
Local pid:
pubs:176350

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