Journal article icon

Journal article

Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria

Abstract:

Background:

The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women.

Methods:...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pntd.0006440

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
ORCID:
0000-0001-5524-0325
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Jittamala, P More by this author
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
12
Issue:
4
Pages:
e0006440
Publication date:
2018-04-20
Acceptance date:
2018-04-10
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pubs id:
pubs:843680
URN:
uri:ec291baf-97a6-43d8-8699-666d2fcd79e3
UUID:
uuid:ec291baf-97a6-43d8-8699-666d2fcd79e3
Local pid:
pubs:843680

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP