- Abstract:
-
Background:
The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women.
Methods:...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.9mb)
-
- Publisher copy:
- 10.1371/journal.pntd.0006440
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Neglected Tropical Diseases Journal website
- Volume:
- 12
- Issue:
- 4
- Pages:
- e0006440
- Publication date:
- 2018-04-20
- Acceptance date:
- 2018-04-10
- DOI:
- EISSN:
-
1935-2735
- ISSN:
-
1935-2727
- Pubs id:
-
pubs:843680
- URN:
-
uri:ec291baf-97a6-43d8-8699-666d2fcd79e3
- UUID:
-
uuid:ec291baf-97a6-43d8-8699-666d2fcd79e3
- Local pid:
- pubs:843680
- Language:
- English
- Keywords:
- Copyright holder:
- Watson et al.
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 Watson et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
Journal article
Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria
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