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One-trial tolerance to the effects of chlordiazepoxide on the elevated plus maze may be due to locomotor habituation, not repeated drug exposure.

Abstract:

The phenomenon of "one-trial tolerance" to the effects of chlordiazepoxide hydrochloride (CDP) in the elevated plus maze was re-examined. Unlike previous experiments, pre-exposure to the maze resulted in habituation and a consequential reduction in time spent on the open arms. The habituation effect was measured by recording the actual distance travelled by the rats in the maze and this was found to be significantly reduced by pre-exposure. Pre-exposure to the maze in the presence of CDP resu...

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Publication status:
Published

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Publisher copy:
10.1007/bf02245242

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Psychopharmacology
Volume:
113
Issue:
3-4
Pages:
570-572
Publication date:
1994-01-05
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:ec279d2c-1fa3-4e46-819b-38367a7981d3
Source identifiers:
29708
Local pid:
pubs:29708

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