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Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells.

Abstract:

The osteoclastogenic factor of osteoblastic origin has recently been elucidated as a novel Tumor Necrosis Factor (TNF)-ligand family member, termed osteoclast differentiation factor (ODF). Using a semiquantitative RT-PCR approach, we sought to determine the mRNA expression of ODF and its decoy receptor, osteoprotegerin (OPG), in a selection of osteoblastic cell lines and in response to three factors representative of different signal transduction pathways, vitamin D receptor, protein kinase A...

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Publisher copy:
10.1210/en.139.11.4743

Authors


Journal:
Endocrinology
Volume:
139
Issue:
11
Pages:
4743-4746
Publication date:
1998-11-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:ec2740b2-06e9-40a8-819f-22c071178e29
Source identifiers:
429436
Local pid:
pubs:429436

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