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The structural characteristics of nonspecific lipid transfer proteins explain their resistance to gastroduodenal proteolysis.

Abstract:

The structure and stability of the allergenic nonspecific lipid transfer protein (LTP) of peach were compared with the homologous LTP1 of barley and its liganded form LTP1b. All three proteins were resistant to gastric pepsinolysis and were only slowly digested at 1 to 2 out of 14 potential tryptic and chymotryptic cleavage sites under duodenal conditions. Peach LTP was initially cleaved at Tyr79-Lys80 and then at Arg39-Thr40 (a site lost in barley LTP1). Molecular dynamics simulations of the...

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Publication status:
Published

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Publisher copy:
10.1021/bi901939z

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
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Journal:
Biochemistry
Volume:
49
Issue:
10
Pages:
2130-2139
Publication date:
2010-03-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:ec1401f2-2f20-4325-b493-8411745ccb93
Source identifiers:
48925
Local pid:
pubs:48925

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