Journal article icon

Journal article

A model for all genomes: the role of transcription factories.

Abstract:
A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2009.10.031

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of molecular biology
Volume:
395
Issue:
1
Pages:
1-10
Publication date:
2010-01-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:ec11c2e7-e62b-422c-8171-9a0d20720a5d
Source identifiers:
1602
Local pid:
pubs:1602

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP