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Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.

Abstract:

Efforts to develop immune-based therapies for HIV infection have been impeded by incomplete definition of the immunological correlates of protection. Despite many precedents demonstrating that CD8(+) cytotoxic T lymphocytes are key mediators of protective anti-viral immunity in non-human animal models, direct evidence that these effector cells control viral replication in HIV-1 infection has remained elusive. The first part of this paper describes a detailed immunological and genetic study fo...

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Publication status:
Published

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Publisher copy:
10.1042/cs19990180

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
Volume:
97
Issue:
6
Pages:
707-718
Publication date:
1999-12-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:ec0f3b7a-b17a-40f2-8ea1-1f59de9da6cd
Source identifiers:
15339
Local pid:
pubs:15339

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