Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing hormone and vasopressin release involving the generation of nitric oxide and carbon monoxide.

Journal article

Although the administration of endotoxin in vivo activates the neuroendocrine stress axis in the process of crosstalk between the immune and endocrine axes, the direct application of endotoxin to the hypothalamus in vitro does not stimulate the release of the hypothalamic peptides controlling the hypothalamo-pituitary-adrenal (HPA) axis, corticotropin-releasing hormone (CRH) and vasopressin. The hypothesis has therefore been tested that endotoxin may also activate inhibitory pathways, specifi...

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Authors: Kostoglou-Athanassiou, I; Costa, A; Navarra, P; Nappi, G; Forsling, M

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 86
• Issue: 1
• Pages: 104-109
• Publication date: 1998-06-01
• DOI: 10.1016/s0165-5728(98)00028-9
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Rats, Wistar; Metalloporphyrins; Protoporphyrins; Vasopressins; Rats; Enzyme Inhibitors; Nitroarginine; Hypothalamus; omega-N-Methylarginine; Lipopolysaccharides; Male; Animals; Carbon Monoxide; Immune System; Heme Oxygenase (Decyclizing); Corticotropin-Releasing Hormone; Nitric Oxide; Cells, Cultured; Neurosecretory Systems