Journal article icon

Journal article

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.

Abstract:

Although there have been major advances in the treatment of rheumatoid arthritis with the advent of biological agents, the mechanisms that drive cytokine production and sustain disease chronicity remain unknown. Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and tissue damage in inflamed rheumatoid joints. Here we show that mice that do not express tenascin-C show rapid resolution of acute joint inflammation and are protecte...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nm.1987

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Piccinini, AM More by this author
Trebaul, A More by this author
Expand authors...
Journal:
Nature medicine
Volume:
15
Issue:
7
Pages:
774-780
Publication date:
2009-07-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:ebf9d5c3-59db-45a1-bb51-3977370733e4
Source identifiers:
224216
Local pid:
pubs:224216

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP