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CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.

Abstract:

1. Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca2+-induced exocytosis in single insulin-secreting mouse pancreatic B-cells. 2. ACh (250 microM) increased exocytotic responses elicited by voltage-clamp depolarizations 2.3-fold. This effect was mediated by activation of muscarinic receptors and dependent on elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) attributable to mobilization of Ca2+ from intracellular stores...

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Publication status:
Published

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Journal:
Journal of physiology
Volume:
518 ( Pt 3)
Issue:
3
Pages:
745-759
Publication date:
1999-08-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
14578

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