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Journal article

'Multicopy multivalent' glycopolymer-stabilized gold nanoparticles as potential synthetic cancer vaccines.

Abstract:

Mucin-related carbohydrates are overexpressed on the surface of cancer cells, providing a disease-specific target for cancer immunotherapy. Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans. A polymerizable version of the Tn-antigen glycan was prepared and converted into well-defined glycopolymers by Reversible Add...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publisher copy

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Publisher copy:
10.1021/ja4046857

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Clemson, NA More by this author
Bernhard, SS More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Funding agency for:
Davis, BG
Journal:
Journal of the American Chemical Society
Volume:
135
Issue:
25
Pages:
9362-9365
Publication date:
2013-06-17
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:ebeca1c5-1cfb-4dca-8125-f94a684d181c
Source identifiers:
407813
Local pid:
pubs:407813

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