Journal article
A brave new world of RNA-binding proteins
- Abstract:
- RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) to change the fate or function of the bound RNAs. Several hundreds of such RBPs have been discovered and investigated over the years. Recent proteome-wide studies have more than doubled the number of proteins implicated in RNA binding and uncovered hundreds of additional RBPs lacking classical RBDs. This review integrates these new RBPs and discusses their possible functions, including the notion that some may be regulated by RNA rather than exerting control over it.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Accepted manuscript, pdf, 4.9MB, Terms of use)
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- Publisher copy:
- 10.1038/nrm.2017.130
Authors
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Reviews Molecular Cell Biology More from this journal
- Volume:
- 19
- Pages:
- 327–341
- Publication date:
- 2018-01-17
- Acceptance date:
- 2017-10-05
- DOI:
- Pubs id:
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pubs:742248
- UUID:
-
uuid:ebe9999f-6553-47e9-a949-06420ccbae03
- Local pid:
-
pubs:742248
- Source identifiers:
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742248
- Deposit date:
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2017-11-02
- ARK identifier:
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2018
- Notes:
- © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/nrm.2017.130
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