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Journal article

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Abstract:

Previously, we reported germline DNA variants associated with risk of urinary bladder cancer (UBC) in Dutch and Icelandic subjects. Here we expanded the Icelandic sample set and tested the top 20 markers from the combined analysis in several European case-control sample sets, with a total of 4,739 cases and 45,549 controls. The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, whi...

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Publication status:
Published

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Publisher copy:
10.1038/ng.558

Authors


Kiemeney, LA More by this author
Besenbacher, S More by this author
Vermeulen, SH More by this author
Sigurdsson, A More by this author
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Journal:
Nature genetics
Volume:
42
Issue:
5
Pages:
415-419
Publication date:
2010-05-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:ebe89ef5-1754-4997-bf1a-11804b126427
Source identifiers:
131072
Local pid:
pubs:131072

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