Journal article
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
- Abstract:
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We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands. Applying this method to primary human bone marrow specimens from patients with Acute Myelogeneous Leukemia (AML), we demonstrated that genetically distinct AML subtypes display diametrically opposed DNA methylation patterns. As compared to normal controls, we obser...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pgen.1002781
Authors
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PLoS Genetics More from this journal
- Volume:
- 8
- Issue:
- 6
- Pages:
- e1002781
- Publication date:
- 2012-06-21
- Acceptance date:
- 2012-05-04
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:344708
- UUID:
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uuid:ebe6f163-9817-4a5e-b46a-1639545e9269
- Local pid:
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pubs:344708
- Source identifiers:
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344708
- Deposit date:
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2013-11-16
Terms of use
- Copyright holder:
- Akalin et al
- Copyright date:
- 2012
- Notes:
- © 2012 Akalin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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