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A functional proteomic method for the enrichment of peripheral membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets.

Abstract:

Platelets are small blood cells vital for hemostasis. Following vascular damage, platelets adhere to collagens and activate, forming a thrombus that plugs the wound and prevents blood loss. Stimulation of the platelet collagen receptor glycoprotein VI (GPVI) allows recruitment of proteins to receptor-proximal signaling complexes on the inner-leaflet of the plasma membrane. These proteins are often present at low concentrations; therefore, signaling-complex characterization using mass spectrom...

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Publication status:
Published

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Publisher copy:
10.1021/pr900027j

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Journal:
Journal of proteome research
Volume:
8
Issue:
6
Pages:
2903-2914
Publication date:
2009-06-05
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:ebe0d553-d1e9-4f81-bbda-a42aa100593a
Source identifiers:
244374
Local pid:
pubs:244374

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