Journal article
Simultaneous pharmacokinetic/pharmacodynamic (PKPD) assessment of ampicillin and gentamicin in the treatment of neonatal sepsis
- Abstract:
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Objectives
This study aimed to simultaneously investigate the pharmacokinetics of ampicillin and gentamicin, currently the WHO standard of care for treating neonatal sepsis.Methods
Pharmacokinetic data were collected in 59 neonates receiving ampicillin and gentamicin for suspected or proven sepsis in the NeoFosfo trial (NCT03453177). A panel of 23 clinical Escherichia coli isolates from neonates with sepsis, resistant to either ampicillin, gen... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 700.0KB, Terms of use)
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- Publisher copy:
- 10.1093/jac/dkab413
Authors
Bibliographic Details
- Publisher:
- Oxford University Press
- Journal:
- Journal of Antimicrobial Chemotherapy More from this journal
- Volume:
- 77
- Issue:
- 2
- Pages:
- 448–456
- Publication date:
- 2020-11-23
- Acceptance date:
- 2021-10-06
- DOI:
- EISSN:
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1460-2091
- ISSN:
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0305-7453
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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1234350
- Local pid:
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pubs:1234350
- Deposit date:
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2022-01-27
Terms of use
- Copyright holder:
- Gastine et al.
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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